---
title: 'Baker Lab publishes AI-designed proteases in Nature'
url: 'https://securteksecurity.com/news/baker-lab-de-novo-ai-designed-proteases-published-in-nature'
markdown: 'https://securteksecurity.com/news/baker-lab-de-novo-ai-designed-proteases-published-in-nature.md'
date: '2026-10-14'
description: 'Researchers at the Baker Lab have published de novo AI-designed proteases in Nature: enzymes designed from scratch to cleave chosen protein sequences. The designs include zinc and cysteine proteases aimed at disease-linked targets such as TDP-43, amyloid-beta, and serum amyloid A, a concrete step f…'
taxonomy:
  category:
    - AI
---

# [Baker Lab publishes AI-designed proteases in Nature](https://securteksecurity.com/news/baker-lab-de-novo-ai-designed-proteases-published-in-nature)

   14th Oct 2026  

Researchers at the Baker Lab have published de novo AI-designed proteases in Nature: enzymes designed from scratch to cleave chosen protein sequences.

The designs include zinc and cysteine proteases aimed at disease-linked targets such as TDP-43, amyloid-beta, and serum amyloid A, a concrete step from predicting protein shapes to building molecular tools.

Sources: [Nature (cysteine proteases)](https://www.nature.com/articles/s41586-026-11143-w), [Nature (metalloproteases)](https://www.nature.com/articles/s41586-026-11167-2), [University of Washington Newsroom](https://newsroom.uw.edu/news-releases/molecular-scissors-open-path-to-new-therapies/)

---

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